Is there a link between PTSD and our body’s immune response?
Well, research published in the Journal of Brain, Behavior, and Immunity has stretched beyond focusing on what happens to the body’s nervous and endocrine systems after trauma. . .
. . . and researchers have discovered a connection between trauma and the body’s immune system. More specifically, researchers have become curious about how trauma affects inflammation – as well as whether inflammation influences the development of PTSD.
Mark Miller, PhD and his team from the Boston University School of Medicine took this one step further. They wanted to look at how epigenetics might influence the link between PTSD and inflammation.
In a study from January 2018, Dr. Miller and his team were able to pinpoint how traumatic stress influences one important gene associated with inflammation, the AIM2 gene.
You see, previous research had identified the protein CRP, C-reactive protein, as a major player in our response to inflammation. CRP can act like an internal firefighter – it puts out the blaze of inflammation in the central and peripheral nervous system.
And the gene most responsible for producing CRP is AIM2.
Now when the immune system is at rest and there is no inflammation, a specific part of AIM2 is methylated – that means the genes are tightly bound together and are turned “off.” And when AIM2 is off, CRP is not being made because there are no fires to put out in the body.
So what can cause AIM2 to switch “on”?
Well, stress can be a big factor – and as we know, stress can contribute to inflammation.
But when AIM2 switches on, it also raises CRP levels in the blood to reduce inflammation.
So these researchers wanted to find out two things. First, did traumatic stress contribute to turning this gene “on?” And second (and perhaps more importantly), if AIM2 didn’t turn on and CRP levels remained low – would that influence the development of PTSD?
In this study, Miller and the team took blood tests of 288 post-9/11 US military veterans who had experienced traumatic stress during deployment in Iraq and/or Afghanistan.
After analyzing their blood samples for CRP levels and doing a clinical assessment of the veterans, the researchers’ findings were two-fold.
They concluded that after traumatic stress, CRP levels are elevated. This means that trauma has an epigenetic influence that turns AIM2 “on.” So trauma can lead to inflammation in the body. But CRP helps to reduce that inflammation.
Now here’s the other implication of the researchers’ findings – people who have experienced trauma but have low CRP levels (either due to a failure in epigenetic control of AIM2 or some other genetic mutation) might be at a higher risk for developing PTSD.
While it’s still too early for these findings to have any immediate clinical application, researchers are hopeful that this study is a step forward in identifying how PTSD impacts gene expression and the body.
Of course, we do need to keep in mind some limitations of this study. The research could have been strengthened by using a control group.
Given that you could not use a randomized design in this study, it would be nice to see a future effort conducted with a prospective design.
If you’d like to read this study for yourself, you can find it in the Journal of Brain, Behavior, and Immunity, volume 67, pp. 194-202.
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Now I’d like to hear from you. What have you found helpful in working with clients who struggle with PTSD?
Please leave a comment below.
This study is just the kind of research that will support my PhD which is specifically looking at the intergenerational transference of trauma through epigenetics
Very promising research, leads me to believe that in the future we could have a blood sample and be able to determine diagnosis. It is amazing how stress affects genetic constitution.
CRP is a protein made mostly in the liver in response to immune system activation anywhere in the body. It is measured frequently along with other routine blood tests to get an idea of how activated the immune system is. It is an “acute phase reactant”, and a “non-specific marker of inflammation”. It functions to INCREASE inflammation and support immune system activity. If your CRP is high, your “inflammation” is high.
CRP supports an effective immune response. We use it in primary care mostly to put cholesterol levels into context, because atherosclerosis is an inflammatory process that itself raises CRP levels, and CRP can be high for other reasons (like infection, injury, autoimmune disease (such as rheumatoid arthritis), obesity, cigarette smoking, sleep disturbance, and other stress states), and high ambient CRP accelerates atherosclerosis, increasing risk.
Inflammation (immune system activation) is the body’s response to actual or perceived danger of any kind. You are getting ready for an attack, getting ready to fight off infection in case you get injured, etc. Or you are already injured and responding to that. The nervous system and the immune system run in parallel. Stress of any kind can increase CRP.
We need the immune system to respond decisively and effectively to problems, then to switch into repair/restore mode and then into resting readiness mode. So, this article is affirming the concept that we need CRP to go up acutely (and then to go back down again, when we switch modes). The article is also making the point that maybe individuals who don’t make a decisive, strong CRP response, (reflected by low CRP level), don’t manage to resolve the problem and end up with a lingering chronic problem instead of healing.
I would not go so far as to say that “when AIM2 switches on it also raises CRP levels in the blood to reduce inflammation”. CRP does not directly reduce inflammation.
CRP RAISES inflammation. CRP indicates inflammation is present. It feels bad. (When you have the flu, your CRP is high and part of its function is making you feel bad so you will rest.). This is a good thing, we need it, but we don’t want to get stuck there. Inflammation, when it is working well, runs up and down an orderly sequence to healing and actually you can’t get to healing without having the initial inflammatory fire (with all the collateral damage) happen first. So, yes, CRP indirectly reduces inflammation but only because it is a big part of the inflammatory fire at the beginning.
This article gets at that ambiguity, which is lost in a lot of discussion of inflammation, which generally sees inflammation as “bad”. You need that strong immune response, but generally you want your CRP to be low at baseline.
The article is looking at a genetic basis for some people being more vulnerable than others– I like to believe that environment is more important than genes; genes are not destiny; maybe knowing there is a certain vulnerability can increase compassion and self-compassion; knowing our vulnerabilities may help us take appropriate action; everybody can heal.
In order to maintain or regain the dynamic flexibility to effectively fight off (or escape from) danger and then exit out of that acute stress state to rest and repair and heal— this process is supported by all of the things we know that are healing– which everyone has listed below.
Body and mind are not separate and never have been.
Thank you. Important clarification and clear explanation.
Great clarification, thank you.
Yes, thank you very much for this clearly stated information!
A very big thank you for the insight on CRP and its role in inflammatory response
We run a 5 week group using art materials and psycho-education to teach skills for lowering arousal and interrupting PTSD symptoms in active ways participants can then fine tune individually. This is usually used as the start of a pathway through treatment. Achieving some sense managing and lowering arousal and symptoms often lowers the desperation associated with acute PTSD symptoms.
The research you feature further supports the importance appearing in so many different forms for all the approaches which focus on ‘resetting’ physiological states, and practicing finding the moments and longer spaces of settled and engaged states. Creative activities have a role to play in helping to access and sustain such states.
Nadija Corcos Art Psychothdrapist
Hello Ruth,
Very insighfull article and explain in detail what’s going on in patients with PTSD and comorbid diagnosis with other mental disease, inflammation and chronic pain.
I’m chilean psychologist and I have a son (28 yo) who has been diagnosed with PTSD and struggles in every day life with inflammation and chronic pain.
I will love to have more info on the subject!!
Best regards,
Helia Martinez
Hi, great article. Finally the importance of the subconscious-mind is being given credence for having a vital role to play in all emotional healing! Here specifically for PTSD and trauma.
Still missing the mark though…. treatment can be applied naturally utilising one’s own inner abilities … there is a gentle private process … Private Subconscious-mind Healing (P.S.H. Therapy – developed here in Australia). Please watch the short film specially produced to understand this concept and its application for emotional healing.
The 3 things that help my traumatized clients the most is:
1. Unlimited positive regard
2. Consistency
3. Respect
I second this
agree
How can I combat this as I have had a traumatic life and I’m full of inflammation thank you Adele
Hi Adele, I have found meditation, breathing exercises and physical exercise (as far as you are able), along with a very low sugar, high in greens diet, are extremely beneficial in addressing inflammation. I have been diagnosed with rheumatoid arthritis.
I hope this helps you.
All the very best,
Mandy
PTSD happens to everyone sometime in their life. The bad genes are passed on from our ancestors. Bad diet smoking also contributes to sickness then passed on to the children.
Certainly, it appears that trauma can be passed on, though the assumption of inevitability of this, is challenged by a host of research on environmental interventions that have been demonstrated to be effective, AND PREVENT trauma over the last 30 years..
Since my focus has been healing trauma throughout my career, I have been drawn to what creates resilience…what “fixes” the physiological changes that we see happening in trauma.
A related question; “Why do 2 people go through similar experiences, and one gets PTSD and the other does not?”
I highly recommend Bruce Perry’s work on Romanian adoptees in the United States, that appeared to have significant brain disorganization because of not being touched and attended too much, as well as the similar outcomes he found in babies born to meth addicted moms.
Similarly, I recommend Dan Siegel’s work, as it has huge implications for what heals the physical changes that come from a lack of integration, as well as what enhances “brain” integration, and structural brain changes.
Check out; “The Neurobiology of We”, and my hope is that you will be inspired towards understanding a lot of the questions that come up in this article about inflammation, as well as what is missing – what causes resiliency, and what heals it?
After being trained in hypnosis in graduate school, and later, indirect inductions, imagery, EMDR, EFT, Herbert Benson’s “The Relaxation Response”, Mindfulness, and all of their ability to structurally change our brains in ways that are highly likely to decrease inflammation, trauma, etc.
Certainly, as Benson has pointed out, most cultures, including indigenous ones, have forms of repetitive physical and mental “practices” integrated in to their spiritual rituals.
He also proved that, for instance, whether you repeat your mantra or just the number 1, the same beneficial structural physical changes in the body occur across a host of measures that he employed…starting at Harvard in the 70’s! (Good news for agnostics and atheists! : )
What’s new IS often old! : )
Andy Hudak LCPC
Whitefish, Mt.
Thank you so much for your detailed response. I didnt ask the question yet I’m thankful it was asked and you took the time to respond. Thank you!
Intriguing. I will research the names and titles you referenced. Thank you very much.
LVD from NJ
Any cure for this?
Only hams get cured. ; )
This extends similar ideas about the role of inflammation in the expression of anxiety and depression.
Just a personal comment. I was diagnosed with attachment-related PTSD several years ago; then my baby died during labour 18 months ago. I am a psychotherapist, not yet qualified but would be if it weren’t for what has happened; i finished the teaching part of my course 18 months ago.
i read a study a while ago about the playing of Tetris being helpful in avoiding the development of PTSD after a potentially traumatic event. i found this particularly interesting as i had been playing Tetris for years. for the last almost 18 months i have been playing another game a great deal, on my phone – one which works in a similar way although without the time constraints of fast-moving Tetris which, whilst absorbing, i think can accentuate anxiety. i wouldn’t say that it’s useful as a treatment or effecting any sort of sea change but, in the moment, in many moments of extreme anxiety and trauma, i think it’s got me through. i would go so far as to say that it’s one of the things that’s kept me alive. i feel that it can be a difficult area as it may seem inappropriate to recommend a client play a computer game, given their general sociocultural perception, but given my personal experience i might do so, carefully, in specific (probably more extreme) cases.
How do you factor in PTSD at the age of 7-20 years old? I do have inflammation, U/C, ulcers and chronic anxiety.
Did any of your studies look at PTSD from childhood?
Now I’m pondering the possible link between PTSD inflammation and my post-TBI headaches.